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Cas No 133407 82 6 Cmp 5 Mce, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with <t>CMP</t> 10A (C) and CMP <t>09C</t> (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with <t>CMP</t> 10A (C) and CMP <t>09C</t> (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with <t>CMP</t> 10A (C) and CMP <t>09C</t> (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with <t>CMP</t> 10A (C) and CMP <t>09C</t> (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.
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lysosome isolation kit  (BOC Sciences)
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with <t>CMP</t> 10A (C) and CMP <t>09C</t> (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.
Lysosome Isolation Kit, supplied by BOC Sciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cmp  (BOC Sciences)
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with <t>CMP</t> 10A (C) and CMP <t>09C</t> (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.
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Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with CMP 10A (C) and CMP 09C (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.

Journal: Frontiers in Pharmacology

Article Title: Restoring the Extracellular Matrix: A Neuroprotective Role for Collagen Mimetic Peptides in Experimental Glaucoma

doi: 10.3389/fphar.2021.764709

Figure Lengend Snippet: Mimetic Peptides are Neurotrophic. Dorsal root ganglia (DRG) explants 24 and 48 h after plating on intact collagen (A) vs. partially digested collagen treated with vehicle (B) . Treatment with CMP 10A (C) and CMP 09C (D) , both at a concentration of 100 μM, increases DRG neurite outgrowth and the area of the field around the explant with neurite coverage compared to vehicle. Scale = 0.5 mm in each direction.

Article Snippet: These were manufactured in limited quantity by Bachem, AG (Germany), with the following sequences: CMP 05A (Pro-Hyp-Gly) 7 , CMP 09C (Pro-trans-Flp-Gly) 6 -Pro-Cys-Gly, CMP 10A (Hyp-Pro-Gly) 7 -P, and CMP 13A (cis-Flp-Hyp-Gly) 7 , where proline (Pro), hydroxyproline (Hyp), glycine (Gly), 4-fluoro-proline (Flp), and the undecapeptide tachykinin neuropeptide substance P (P) are abbreviated as indicated.

Techniques: Concentration Assay

Neurite Outgrowth Following CMP Treatment. Longest neurite outgrowth (A) and explant field area (B) at 48 h normalized to their values for intact collagen (n = 178). Explants plated on digested collagen and treated with vehicle only (n = 139) demonstrate significantly diminished neurite length ( p = 0.014) and field area ( p < 0.001) compared to intact collagen (#). Treatment with CMPs 10A (n-17) and 09C (n = 16) extended the longest neurites, significantly beyond even intact collagen (*, p ≤ 0.036), while CMPs 13A (n = 17) and 10A increased field area compared to vehicle (*, p ≤ 0.03).

Journal: Frontiers in Pharmacology

Article Title: Restoring the Extracellular Matrix: A Neuroprotective Role for Collagen Mimetic Peptides in Experimental Glaucoma

doi: 10.3389/fphar.2021.764709

Figure Lengend Snippet: Neurite Outgrowth Following CMP Treatment. Longest neurite outgrowth (A) and explant field area (B) at 48 h normalized to their values for intact collagen (n = 178). Explants plated on digested collagen and treated with vehicle only (n = 139) demonstrate significantly diminished neurite length ( p = 0.014) and field area ( p < 0.001) compared to intact collagen (#). Treatment with CMPs 10A (n-17) and 09C (n = 16) extended the longest neurites, significantly beyond even intact collagen (*, p ≤ 0.036), while CMPs 13A (n = 17) and 10A increased field area compared to vehicle (*, p ≤ 0.03).

Article Snippet: These were manufactured in limited quantity by Bachem, AG (Germany), with the following sequences: CMP 05A (Pro-Hyp-Gly) 7 , CMP 09C (Pro-trans-Flp-Gly) 6 -Pro-Cys-Gly, CMP 10A (Hyp-Pro-Gly) 7 -P, and CMP 13A (cis-Flp-Hyp-Gly) 7 , where proline (Pro), hydroxyproline (Hyp), glycine (Gly), 4-fluoro-proline (Flp), and the undecapeptide tachykinin neuropeptide substance P (P) are abbreviated as indicated.

Techniques: